Antibacterial Hydrogel Coating Protection for Implanted Biomaterials

  Implanted biomaterials may get colonized by bacteria during surgery...


Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.


Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.

VIDEO of biofilm formation


An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.

Antibacterial coatings classification


DAC (Defensive Antibacterial Coating) is

the first fully resorbable coating specifically designed

to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. 



Risultati immagini per dac hydrogel


Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)





Mechanism of Implant-Related Infection

  DAC Barrier Effect

Surgical Technique



Scientific Background


Gels 2024

Recent Advancements in Hydrogel Biomedical Research in Italy


 Molecules 2024

Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections


Medicina 2024

What to Know about Antimicrobial Coatings in Arthroplasty: A Narrative Review




 Gels 2023 

Hydrogel Coating versus Calcium Sulphate Beads in Acute Periprosthetic Joint Infection


Advances in Hygiene and Experimental Medicine 2023

Defensive antibacterial coating (DAC) hydrogel for the therapy of achilles tendon infection 


J Adv Health Care 2023 

Incidence and Cost of Post-Operative Wound Infections in Patients Treated or Untreated with DAC® Antibacterial Hydrogel


 Materials 2023

 Defensive Antibacterial Coating (DAC®) in Orthopaedic Surgery: A Narrative Review


Materials Today Bio 2023

 Antibacterial coatings on orthopedic implants


 Antibiotics 2023

Local Antibiotic Delivery Options in Prosthetic Joint Infection


AMB Expr 2023

 A fabricated hydrogel of hyaluronic acid/curcumin to heal the bacterial infected wound


Antibiotics 2023

 Antibiotic-Loaded Coatings to Reduce Fracture-Related Infections 


Frontiers in Bioengineering and Biotechnology 2023

 Potential side effects of antibacterial coatings in orthopaedic implants


 Pharmaceutics 2023

Polysaccharide-Based Coatings as Drug Delivery Systems




Int J Artif Organs 2022

 High Rate of Infection Eradication Following Cementless One-Stage Revision Hip Arthroplasty with an Antibacterial Hydrogel Coating.


 J Bone Joint Infect 2022

Implant surface modifications as a prevention method for periprosthetic joint infection: a systematic review and meta-analysis


 Research, Society and Development 2022

  Utilização do hidrogel (DAC) na prevenção de infecções em procedimentos com fixação interna estável (FIE):Revisão sistemática da literatura  


MO-Journal 2022

Antibacterial Coating of Implants: What Surgeons Should Know


Pharmaceutics 2022

 High Molecular Weight Hyaluronic Acid Reduces the Expression of Virulence Genes


Int J Mol Sci 2022

 Rapidly Aging Society and the Need for Multifunctional Bioactive Coatings for Orthopedic Applications


Gels 2022

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance




  Eur J Orthop Traumatol 2021

DAC®  Antibacterial Hydrogel Coating for Megaprosthesis


Gels 2021

Clinical Application of Antibacterial Hydrogel and Coating in Orthopaedic and Traumatology Surgery


Surg Technol Int 2021

 Antibiotic-Loaded Hydrogel Coating for the Prevention of Local Infection after Vertebral Surgery


 J Orthop Res. 2021 

Single-stage Revision of MRSA Orthopedic Device-related Infection in Sheep with an Antibiotic-loaded Hydrogel


 National Science Review 2021

Functional Hydrogel Coating


Injury 2021

 Reconstruction of infected post-traumatic bone defects of the distal femur


  Brazilian Journal of Oral and Maxillofacial Surgery 2021

 Hidrogel Sobre Material de Fixação em Cirurgias Maxilofaciais


 Advances in Oral and Maxillofacial Surgery 2021

Protective Hydrogel to Heal Post-maxillofacial Surgery Paresthesia?




Protet Stomatol 2020

DAC® Hydrogel in Maxillo-Facial Surgery: a Case Report


 Frontiers in Medicine 2020  

The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel 


 Hip International 2020 

Antibiotic-loaded Hydrogel Coated Revision Hip Prosthesis 


Paper of the Week


  ICM Philly   October 13, 2020


 Journal of Bone and Joint Infection 2020 

Antimicrobial Coated Orthopaedic Implants Efficacy:

a Systematic Review and Meta-Analysis


 ClinicalTrials 2020 

Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery 


 Biomolecules 2020 

Stability Evaluation and Degradation Studies of DAC® Hyaluronic-Polylactide Based Hydrogel by DOSY NMR Spectroscopy


Microorganisms 2020

Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery


ECM 2020 

Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits


Muscles, Ligaments and Tendons Journal 2020

Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study




Traumatology and Orthopedics of Russia 2019

Local Antibacterial Implant Protection in Orthopedics and Trauma: What’s New ?


Bone & Joint Research 2019

Antibacterial coating of implants: are we missing something? 


Eur Rev 2019

Orthopaedic oncology and antibacterial coatings


Maitrise Orthopedique Journal 2019

Surgical Technique and Clinical Applications (see full text below)




JOA 2018

Cost-benefit balance of DAC and other antibacterial coatings 


Dr. Willemijn Boot - PhD thesis 2018 

Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands


 Int Orthop 2018

Two-stage hip revision with DAC coating provides better results than without


 Hydrogels 2018

Hydrogel coating: from basic research to clinical applications


KSSTA 2018

Clinical application to one-stage revision of PJI


Orthop Proceedings 2018

Clinical application to two-stage hip revision of PJI


Antibacterial Coating of Implants in Ortho-Trauma - Springer Ed. 2018




 JORT 2017

 Clinical application to osteosynthesis and fracture fixation devices 


JBJI 2017

 Anti-adhesive and anti-bacterial effects of hyaluronic acid


CORR 2017

No interference of antibiotic-looaded hydrogel with bone healing in the animal model


 BJJ 2017-2 


BJJ 2017-1




Chapter 9. Infection after Joint Arthroplasy - Thieme Ed. 2017

 by A. Chen, CL Romanò, L Drago, J Parvizi




JBJI 2016

Clinical application to joint prosthesis


 BJJ 2016-1


BJJ 2016-2


Med Inflamm 2016


 Copertina anteriore 

Paradigm change in antibacterial coatings - Springer Ed. 2016




JOSR 2015

Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal


 Orthop Today 2015


A Barrier Against Implant-Related Infections

Risultati immagini per dac hydrogel


Clinical Indications

DAC is a CE marked medical device, specifically designed to protect implanted biomaterials from bacterial adhesion and colonization, in order to reduce or prevent the occurrence of post-surgical infections.

The device can be used to protect cementless and hybrid (partially cemented) joint prosthesis (hip, knee, shoulder, etc.), fracture fixation devices (plates, nails, screws, etc.), dental implants, etc..

All patients may take advantage from the antibacterial protection offered by DAC hydrogel, that is especially useful for those patients at higher risk for infection (e.g.: old-aged patients, diabetic and/or obese, smokers, alcohol or drug abusers, immunocompromised hosts, malnurished or oncological patients, etc.) and/or undergoing high risk procedures (revision or tumor surgery, contaminated procedures, etc.).


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D.A.C.: The Result of an International Collaborative Project

DAC is the result of a international project, funded by the European Community under the 7th Framework Programme, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs.

To learn more, visit the official website of  iDAC Project